Jason Goodger, from the School of BioSciences at the University of Melbourne. The chemical for this trial was isolated from the leaves of eucalyptus saplings at the University of Melbourne's Dookie campus by Dr. 'In lung fluid samples, inflammatory cells called neutrophils dropped from 7.4 percent of total cells to 3.7 percent in the pinocembrin-treated bleomycin-injured lung segments.' 'We saw striking anti-inflammatory effects and modest anti-fibrotic remodeling after four weeks of administering pinocembrin.'Ĭo-lead author Professor Ken Snibson, also from the Melbourne Veterinary School, explained there was a 50 percent reduction in certain inflammatory cells in the lungs. 'We found that pinocembrin improved lung function, attenuated lung inflammation, and decreased overall pathology scores compared to damaged lungs that were untreated,' Dr.

Habamu Derseh, from the Melbourne Veterinary School in the Faculty of Veterinary and Agricultural Sciences at the University of Melbourne said the results were 'striking.' One of the segments was treated with 7mg of pinocembrin once weekly for four weeks, while the other segment was left untreated.Ĭo-lead author on the study, Dr.

In the study, published today in PLOS One, the fibrosis was induced in two localized lung segments in each of the sheep. Researchers from the University of Melbourne, Monash University, Swinburne University of Technology and industry partner Gretals Australia, set out to test the anti-inflammatory and anti-fibrosis properties of pinocembrin in 10 sheep, to see whether the compound could be effective at treating lung fibrosis. Pinocembrin, a flavonoid found in several different type of trees including pine trees and eucalyptus, has been reported to have antioxidant, anti-inflammatory, anti-microbial and anti-cancer properties.

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